Abdominal volume contribution to tidal volume as an early indicator of respiratory impairment in Duchenne muscular dystrophy

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Abdominal volume contribution to tidal volume as an early indicator of respiratory impairment in Duchenne muscular dystrophy.

Duchenne muscular dystrophy (DMD) is characterised by progressive loss of muscular strength that leads to an increasingly restrictive pulmonary syndrome. However, it is still not clear whether this determines alterations in the breathing pattern. We studied: 66 DMD patients at different stages of the disease (mean+/- sem age 12.6+/-0.6 yrs, range 5-22 yrs of age), subdivided into four groups ac...

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Adequate tidal volume with row-a-boat phenomenon in advanced Duchenne muscular dystrophy.

1 Kazerooni EA, Chow LC, Whyte RI, et al. Preoperative examination of lung transplant candidates: value of chest CT compared with chest radiography. AJR Am J Roentgenol 1995; 165:1343–1348 2 McKenna RJ Jr, Fischel RJ, Brenner M, et al. Combined operations for lung volume reduction surgery and lung cancer. Chest 1996; 110:885–888 3 Pigula FA, Keenan RJ, Ferson PF, et al. Unsuspected lung cancer ...

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Duchenne muscular dystrophy An overview of Duchenne muscular dystrophy

Duchenne muscular dystrophy (DMD) affects approximately 1 in 3,500 live male births [1]. It is caused by a large variety of mutations in the dystrophin gene. Because of these mutations, the body can no longer make dystrophin which is a protein important for stabilisation of the muscle cell during a contraction. Without dystrophin, muscle cells are damaged and slowly replaced by fat and scar tis...

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Respiratory muscle training in Duchenne muscular dystrophy.

Eighteen boys with Duchenne muscular dystrophy were entered into trials to assess the effects of specific ventilatory strength and endurance training programmes. The findings showed an improvement in ventilatory muscle endurance but not in strength as a result of specific respiratory muscle training. The clinical significance of these findings is uncertain, however, and needs further evaluation.

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P164: Adeno-Associated Viral Vectors in Duchenne Muscular Dystrophy

Duchenne muscular dystrophy (BMD) is an inherited X-link disease. The incidence of this muscle-wasting disease is 1:5000 male live births. Mutation in the gene coding for dystrophin is the main cause of BMD. Most cases of this disease succumb to respiratory and cardiac failure in 3rd to 4th decades. The slow progression of BMD and recent achievement of gene therapies make it as an appropriate c...

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ژورنال

عنوان ژورنال: European Respiratory Journal

سال: 2009

ISSN: 0903-1936,1399-3003

DOI: 10.1183/09031936.00037209